Dr. Lark J. Perez
November 1, 2017
11:00 – 11:50 am
C – 121
“Investigations of Chemical Signaling in Bacterial Pathogens”
Bacterial and mammalian cells carefully regulate cellular processes using chemical signaling. In mammalian cells, one example of chemical signaling regulation is in the resolution of inflammation triggered by the small-molecule Lipoxin A4. Bacterial pathogens such as Pseudomonas aeruginosa regulate virulence factor expression and biofilm formation through their own specialized chemical signaling pathways using a process commonly known as quorum sensing (QS). I will describe our discovery of the sensing of the mammalian signaling molecule Lipoxin A4 by P. aeruginosa and our investigations into the inhibition of QS-regulated virulence in this bacteria.